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KMID : 1189420060190010103
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2006 Volume.19 No. 1 p.103 ~ p.114
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Experimental Effects of Taklihwajung-Tang on the Proliferation of Cancer Cells and Immunocytes
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Lee Jun-Hun
Park Su-Yeon
Kim Jong-Han
Choi Jung-Hwa
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Abstract
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Objective: The purpose of this study was to investigate effects of Taklihwajung-Tang on the proliferation of cancer cells land immunocytes focusing around combined effects of anticarcinogen.
Materials and Method: We used Taklihwajung-Tang extract(THT) with freeze-dried, 8wks-old male balb/c mice and cancer cell lines(L1210, S-180) for this study. The proliferation of cells was tested using a colorimetric tetrazoliun assay(MIT assay).
Results and Conclusion: The results of this study were obtained as follow ; 1. THT was significantly showed cytotoxicity on the L1210 cell lines and S-180 cell lines. 2. THT was significantly increased in the proliferation of thymocytes and splenocytes in vitro. 3. In combined effects of THT and vincristine(0.005mg/kg), THT was significantly inhibited proliferation of S-180 cell lines compared with positive control group. 4. In combined effects of THT and vincristine(0.005mg/kg), THT was significantly decreased in the weight of sarcoma compared with positive control group. 5. In combined effects of THT and vincristine, THT was significantly inhibited the hematological side reaction compared with positive control group. The present author thought that THT had action of anti-cancer and immune-activity, and in combined effects of vincristine, THT had recoverable effects on damage by anticarcinogen.
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KEYWORD
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Taklihwajung-Tang, CancerCell, Immunocyte
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